CXADR/CAR His Tag Protein, Human,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Human
Synonyms	CXADR, CAR, CAR4/6, HCAR
Accession	NP_001329.1
Amino Acid Sequence	Leu20-Gly237 with His Tag at C-Terminus
Expression System	HEK293
Molecular Weight	30-33kDa (Reducing)
Purity	＞95% by SDS-PAGE & SEC-HPLC
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4, 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Seuthe IMC, Krause L, Ruwe M, Silling S, Ehrhardt A, Eichhorn S, Ehrke-Schulz E, Park JJ. Expression and prognosis of DSG-2, CXADR, CD46 in head and neck squamous cell carcinoma. Pathol Res Pract. 2024 Oct; 262:155541.

Background

Coxsackie virus and adenovirus receptor (CXADR), also known as CAR, is a type I transmembrane glycoprotein that serves as a receptor for group B coxsackie viruses and subgroup C adenoviruses. It belongs to the CTX family within the immunoglobulin (Ig) superfamily. CAR is strongly expressed in the developing central nervous system and functions as both a homophilic and heterophilic cell adhesion molecule through its interactions with extracellular matrix glycoproteins, including fibronectin, agrin, laminin-1, and tenascin-R.
The human CXADR protein consists of a signal sequence, an extracellular domain (ECD) with a V-type (D1) and a C2-type (D2) Ig-like domain, a transmembrane segment, and an intracellular domain. The D1 domain is believed to be responsible for homodimer formation within tight junctions and is necessary and sufficient for adenovirus binding. Variants of CXADR are anchored to the cell membrane by a glycosylphosphatidylinositol (GPI) anchor.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.