ENPP3/CD203c Fc Chimera Protein, Mouse,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Mouse
Synonyms	EC:3.1.4.1，E-NPP 3，PD-Ibeta，NPPase，CD203c，PDNP3，Phosphodiesterase I/nucleotide pyrophosphatase 3，Nucleotide diphosphatase，ENPP3，DJ914N13.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3)，Phosphodiesterase-I Beta，Phosphodiesterase I Beta，CD203c Antigen，Gp130RB13-6，NPP3，B10，Ectonucleotide pyrophosphatase/phosphodiesterase family member 3，Ectonucleotide Pyrophosphatase/Phosphodiesterase 3，DJ1005H11.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3)，EC:3.6.1.9
Accession	Q6DYE8
Amino Acid Sequence	Arg46-Ile874 with Human IgG1 Fc Tag at N-Terminus
Expression System	HEK293
Molecular Weight	110-150kDa (Reducing)
Purity	＞95% by SDS-PAGE &＞90% by SEC-HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	Human IgG1 Fc
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4, 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.Yao, Wang, Han et al.[J] J Transl Med. (2023) 21 (1), 594.

Background

ENPP3 (CD203c, ENPP3) is a member of the human NPP (Nucleotide Pyrophosphatase/Phosphodiesterase) family. It is expressed in various organs, including on epithelial and mucosal surfaces, and is particularly notable on basophils and mast cells. NPP3 serves as a common marker for diagnosing allergen sensitivity by analyzing patient basophils using flow cytometry.
Basophils and mast cells play a role in mediating responses to certain pathogens as well as acute and chronic allergic reactions. Upon activation, these cells release ATP, which further stimulates them in an autocrine manner. The upregulation of NPP3 helps to degrade ATP and suppresses chronic allergic inflammation, without affecting the acute response.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.