CD40 Fc Chimera Protein, Mouse,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Mouse
Synonyms	Bp50, CDW40, MGC9013, TNFRSF5, p50
Accession	P27512-1
Amino Acid Sequence	Val24-Arg193 with Human IgG1 Fc at C-Terminus
Expression System	HEK293
Molecular Weight	50-55kDa (Reducing)
Purity	＞95% by SDS-PAGE & SEC-HPLC
Conjugation	Unconjugated
Tag	Human IgG1 Fc
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4, 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.Hanlon MM, Smith CM, Canavan M, Neto NGB, Song Q, Lewis MJ, O'Rourke AM, Tynan O, Barker BE, Gallagher P, Mullan R, Hurson C, Moran B, Monaghan MG, Pitzalis C, Fletcher JM, Nagpal S, Veale DJ, Fearon U. Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset. Sci Adv. 2024 Sep 27;10(39):eadj1252.

Background

CD40, also known as TNFRSF5, Bp50, CDW40, MGC9013, or p50, is a member of the tumor necrosis factor (TNF) receptor superfamily. This family consists of single transmembrane-spanning glycoproteins that play crucial roles in mediating a broad range of immune and inflammatory responses. CD40 is particularly important for T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.
CD40 features four cysteine-rich repeats in its extracellular domain and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. The extracellular domain of CD40 contains cysteine-rich repeat regions, which are characteristic of many receptors within the TNF superfamily.
The interaction of CD40 with its ligand, CD40L, leads to the aggregation of CD40 molecules. These aggregated molecules then interact with cytoplasmic components to initiate signaling pathways. Early studies on the CD40-CD40L system highlighted its role in humoral immunity. Defects in the CD40 pathway can result in hyper-IgM immunodeficiency type 3 (HIGM3), an autosomal recessive disorder. This condition is characterized by an inability of B cells to undergo isotype switching and to mount an antibody-specific immune response, as well as a lack of germinal center formation.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.