Fas/TNFRSF6/CD95 Fc Chimera Protein, Mouse,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Mouse
Synonyms	ALPS1A, APO1, APT1, FAS1, FASTM, FasR
Accession	P25446
Amino Acid Sequence	Gln22-Arg169 with Human IgG Fc at the C-Terminus
Expression System	HEK293
Molecular Weight	47-60kDa(R)
Purity	＞95% by SDS-PAGE & SEC
Conjugation	Unconjugated
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, PH7.4, 5% trehalose
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Xie C, Yang S, Li Y, Zhang M, Xu Q, Wan Z, Song L, Lv Y, Luo D, Li Q, Wang Y, Chen H, Mei S. Associations of exposure to organochlorine pesticides and polychlorinated biphenyls with chronic kidney disease among adults: the modifying effects of lifestyle. Environ Sci Pollut Res Int. 2024 Jul 3.

Background

Fas, also known as the FAS receptor (FasR), apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95), or tumor necrosis factor receptor superfamily member 6 (TNFRSF6), is a cell surface death receptor that triggers programmed cell death, or apoptosis. In mice, the FasR gene is located on chromosome 19, and orthologous sequences, which are evolutionarily related, are present in most mammals.
Recent research has indicated a dual role for Fas in cancer biology. While it is traditionally associated with the induction of apoptosis, it has also been shown to promote tumor growth. During tumorigenesis, Fas is often downregulated, or tumor cells may develop resistance to apoptosis. Regardless of their sensitivity to Fas-mediated apoptosis, cancer cells generally rely on the constitutive activity of Fas for optimal growth. This activity is often stimulated by the Fas ligand, which is produced by the cancer cells themselves.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.