CD117/c-Kit His Tag Protein, Cynomolgus,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Cynomolgus
Synonyms	CD117, SCFR, c-Kit, KIT
Accession	XP_005555332.1
Amino Acid Sequence	Gln26-Pro520, with C-terminal His
Expression System	HEK293
Molecular Weight	75-95kDa (Reducing)
Purity	＞95% by SDS-PAGE &＞SEC-HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, 5% trehalose, PH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1. Wang H, Ni R, Wang A, Liu B. CD117 expression predicted FLT3 mutation in T-cell acute lymphoblastic leukemia. EJHaem. 2024 Feb 18;5(1):294-295. 2. Jiang YJ, Zhang CF, Wang HX, Zhao L, Zhang FF, Han XH. [Clinical Significance of Genetic and Molecular Changes in Primary Myeloid Sarcoma]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2024 Feb;32(1):27-32. Chinese.

Background

Mast/stem cell growth factor receptor Kit (c-Kit), a member of the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily, is also known as piebald trait protein (PBT), p145 c-kit, tyrosine-protein kinase Kit and CD117,which contains five Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. CD117 acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.