IL-21 Protein, Rat,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Rat
Synonyms	Interleukin-21, IL-21
Accession	A3QPB9
Amino Acid Sequence	His18-Ser146
Expression System	E.coli
Molecular Weight	15kDa
Purity	＞95% by SDS-PAGE&RP-HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	20mM Tris, 400mM NaCl, pH8.0
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.J Immunotoxicol. 2016 May;13(3):274-85. 2.Epub 2015 Oct 28. 2.Front Cell Infect Microbiol. 2019 Dec 4:9:401. 3.eCollection 2019. 3.Med Oncol. 2023 May 30;40(7):191.

Background

Cytokines are considered important factors in the modulation of various immune responses. Among them, interleukin (IL)-21 is one of the major immune modulators, adjusting various immune responses by affecting various immune cells. It has been suggested that IL-21 may enhance autoimmunity through different mechanisms, such as development and activation of helper T (TH)-17 and follicular helper T (TFH) cells, activation of natural killer (NK) cells, enhancing B-cell differentiation and antibody secretion and suppression of regulatory T (Treg) cells. Actually IL-21 is a pleiotropic cytokine whose functions in protection and immunopathology during parasitic diseases have been explored in limited ways, and it has been revealed to elicit antitumor-immune responses in several tumor models.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.