Ubiquitin-specific protease 14 (USP14), a deubiquitinating enzyme (DUB), is associated with
proteasomes and exerts a dual function in regulating protein degradation. USP14 protects
protein substrates from degradation by removing ubiquitin chains from proteasome-bound
substrates, whereas promotes protein degradation by activating the proteasome. Increasing
evidence have shown that USP14 is involved in several canonical signaling pathways, correlating with cancer, neurodegenerative diseases, autophagy, immune responses, and
viral infections. The activity of USP14 is tightly regulated to ensure its function in various cellular processes. Due to its intriguing roles in the stabilization of disease-causing proteins and oncology targets, USP14 has garnered widespread interest as a therapeutic target.
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