CSPG4 (also known as neuron-glial antigen 2, NG2, and high molecular weight-melanoma associated antigen, HMW-MAA) is key component of cell migration and proliferation. CSPG4 has been associated with disease severity in other tumors. Expression of CSPG4 could be a useful prognostic biomarker in chordoma. As CSPG4 is expressed on the cell-surface, it is also an attractive candidate for targeting by a CSPG4-specific antibody.