Galectin-4 His Tag Protein, Human,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Human
Synonyms	Galectin-4, LGALS4, L36LBP, Antigen NY-CO-27, Lactose-binding lectin 4
Accession	P56470-1
Amino Acid Sequence	Met 1-Ile323, with N-8*His
Expression System	HEK293
Molecular Weight	38-42kDa
Purity	>95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4, 2mM DTT
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1、Yang R Y. et al. 2008 Galectins: structure, function and therapeutic potential. Expert Rev Mol Med. 10: e17. 2、Ideo H. et al. 2007 Recognition mechanism of galectin-4 for cholesterol 3-sulfate. J Biol Chem. 282(29): 21081-21089.

Background

Galectins are a family of carbohydrate-binding proteins with specificity for N-acetyl-lactosamine-containing glycoproteins.Galectin-4, a tandem-repeat-type lectin with affinity to sulfatide and nonsialylated termini of N-glycans, has the ability to regulate adhesion of cells to ECM components and is also involved in polarized membrane trafficking.Galectin-4 expression is concentrated within microvilli in the gastrointestinal epithelium, where it can interact with CD3 and bind activated T cells in the lamina propria during intestinal inflammation. Galectin-4 can also bind lung, spleen and kidney macrophages, although its expression is normally low in these tissues. Neurons and OLGs were identified as a possible source of galectin-4, both in vitro and in vivo. In culture, neurons but not OLGs released galectin-4. In co-cultures, a reduced release of endogenous galectin-4 correlated with the onset of myelination. Galectin-4-reactive sites are transiently expressed on processes of premyelinating primary OLGs, but not on neurons. Neuronal galactin-4 is a candidate for a soluble regulator of OLG differentiation and myelination.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.