Cereblon (CRBN; a member of the ATP-dependent Lon protease) is an enzyme implicated in memory and learning. Interestingly, CRBN and KCa1.1 are both highly expressed in the same areas of the brain, including the hippocampus, which is known for its involvement in memory and learning. These two proteins bind directly to each other via the C-terminus of KCa1.1 in vitro, and their proximity in brain has been confirmed biochemically and by visualization of immunolabeled complexes in cultured hippocampal neurons. Ectopically expressed CRBN suppresses KCa1.1 surface expression by disrupting the formation of tetramers and therefore functional channels. The physiological consequences of the interaction between CRBN and KCa1.1 remain to be explored, although inherited mutations of the human cereblon gene (CRBN) or KCa1.1 lead to mental retardation disorders. And Substrate Recognition Component Of A DCX (DDB1-CUL4-X- Box) E3 Protein Ligase Complex That Mediates The Ubiquitination And Subsequent Proteasomal Degradation Of Target Proteins, Such As MEIS2. Regular Degradation Of Key Regulatory Proteins Is Necessary For Normal Limb Outgrowth And Expression Of The Fibroblast Growth Factor FGF8.
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