FGF-21 Protein, Mouse,UA BIOSCIENCE_specification/price/image

Product Detail
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Product Specification

Species	Mouse
Synonyms	FGF-21, Fibroblast growth factor 21
Accession	Q9JJN1
Amino Acid Sequence	Ala29-Ser210
Expression System	E.coli
Molecular Weight	20kDa
Purity	>95% by SDS-PAGE & RP-HPLC
Endotoxin	<1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	20mM PB, 150mM NaCl, pH 7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1、Kharitonenkov A J. et al. (2005) FGF-21 as a novel metabolic regulator. J Clin Invest. 115(6): 1627-1635. 2、Guo A. et al. (2020) Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets? Exp Gerontol. 139: 111022. 3、Gomarasca M. et al. (2020) Myokines: The endocrine coupling of skeletal muscle and bone. Adv Clin Chem. 94: 155-218.

Background

Fibroblast Growth Factor 21(FGF-21) is a member of the fibroblast growth factor (FGF) family and it is involved in the modulation of cell proliferation, growth, and differentiation as well as cell metabolism. This protein is a secreted endocrine factor that functions as a major metabolic regulator, and stimulates the uptake of glucose in adipose tissue. FGF21 binds to FGFR1c complexed with β-Klotho expressed in adipocytes to activate the canonical FGF signaling pathway (ERK1/2) and the AMPK/PGC1α pathway. Therefore, FGF-21 is being pursued as a therapeutic target for diabetes and obesity.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.