IL-21 Protein, Mouse,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Mouse
Synonyms	IL-21, rMuIL-21, Za11
Accession	Q9ES17
Amino Acid Sequence	Pro25-Ser146
Expression System	E.coli
Molecular Weight	14kDa
Purity	>95% by SDS-PAGE
Endotoxin	<1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	20mM Tris, 100mM NaCl, pH8.0
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1、Coquet J M. et al. (2007) IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J Immunol. 178(5):2827-34. 2、Wei L. et al. (2007) IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem. 282(48):34605-10. 3、Parrish-Novak J. et al. (2002) Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J Leukoc Biol. 72(5):856-63. 4、Kuchen S. et al. (2007) Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration. J Immunol. 179(9): 5886-96.

Background

IL-21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. IL-21 is a T-cell–derived cytokine that works in concert with other γc cytokines. It synergizes with IL-7 and IL-15 to expand and activate CD8 T cells. IL-21 also augments the activity of NK cells. IL-21, along with IL-6, drives differentiation of Tfh. Tfh cells are found preferentially in B-cell follicles, where, under the control of the transcription factor BCL6, they regulate B-cell development, activation, and class switching. Tfh cells are also a source of IL-21. IL-21 appears to have some anticancer properties, and it has been tested in the treatment of melanoma.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.