Thrombomodulin His Tag Protein, Human,UA BIOSCIENCE_specification/price/image

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Product Specification

Species	Human
Antigen	Thrombomodulin
Synonyms	TM
Accession	P07204
Amino Acid Sequence	Ala19-Ser515, with C-terminal 8* His APAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLMTVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYSRWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAVEPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPNTQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHSGGGSHHHHHHHH
Expression System	HEK293
Molecular Weight	72-83 kDa (Reducing)
Purity	＞95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.Pindon A, Hantai D, Jandrot-Perrus M, Festoff BW.Novel expression and localization of active thrombomodulin on the surface ofmouse brain astrocytes. Glia 1997; 19: 259– 68. 2.Shibata M, Kumar SR, Amar A, Fernandez JA, Hofman F, Griffin JH, ZlokovicBV. Anti-inflammatory, antithrombotic, and neuroprotective effects of activatedprotein C in a murine model of focal ischemic stroke. Circulation 2001; 103:1799– 805.

Background

Thrombomodulin (TM) is a transmembrane glycoprotein located on the luminal surface of endothelial cells in most normal blood vessels that regulates coagulation and inflammation. Encoded by an intronless gene on chromosome 20, the mature single-chain TM glycoprotein in the human is 557 amino acids long, structurally organized into five distinct regions, including the cytoplasmic and transmembrane domains, a serine/threonine-rich region with an attached chondroitin sulfate moiety, six consecutive EGF-like repeats, and the N-terminal lectin-like domain. Thrombomodulin is an endothelial cell thrombin receptor that converts thrombin into an anticoagulant capable of activating protein C, suggesting a protective role in thrombosis. TM may also affect astrocyte function and protect against thrombin-induced neuronal cell death via an APC-dependent mechanism.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.