Interleukin 7
Receptor alpha (IL-7 R alpha ), also known as CD127, is a 75 kDa hematopoietin
receptor superfamily member that plays an important role in lymphocyte
differentiation, proliferation, and survival. IL-7 R alpha associates with the
common gamma chain ( gamma c) to form the functional high affinity IL-7
receptor complex. The gamma c is also a subunit of the receptors for IL-2, -4,
-9, -15, and -21. IL-7 R alpha is expressed on double negative (CD44-/CD8+) and
CD4+ or CD8+ single positive T cells as well as on CD8+ memory T cells and
their precursors. It is expressed early in B cell development, prior to the
appearance of surface IgM. In mouse, IL-7 activation of IL-7 R alpha is
critical for both T cell and B cell lineage development. IL-7 induces the
downregulation and shedding of cell surface IL‑7 R alpha.IL-7 R
alpha additionally associates with TSLP R to form the functional receptor for
thymic stromal lymphopoietin.TSLP indirectly regulates T cell development by
modulating dendritic cell activation.
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