LAG3 is a member of
the immunoglobulin superfamily and a CD4 ancestral homolog, resulting from a
gene duplication event. Like CD4, LAG3 binds MHC class II (MHCII), but also FGL-1,α-synuclein
fibrils (α-syn) and the lectins galectin-3 (Gal-3) and lymph node sinusoidal
endothelial cell C-type lectin (LSECtin). As an immune checkpoint, LAG3
inhibits the activation of its host cell and generally promotes a more
suppressive immune response. On T cells, LAG3 reduces cytokine and granzyme
production and proliferation while encouraging differentiation into T
regulatory cells.
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