Human SERPINF1 gene
codes for pigment epithelium-derived factor, a secreted glycoprotein and member
of the SERPIN superfamily. Pigment epithelium-derived factor, also known as
PEDF, Serpin F1, and SERPINF1, is a multiple functional protein that has both
anti-angiogenic activity and neurotrophic activity at the same time.PEDF has
affinity for PEDF-receptor (PEDF-R), a membrane-linked lipase encoded by the
PNPLA2 gene.PEDF is also responsible for apoptosis of endothelial cells either
through the p38 MAPK pathway or through the FAS/FASL pathway.PEDF has a variety
of functions including antiangiogenic, antitumorigenic, and neurotrophic
properties.
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