The
TSLP receptor (TSLPR, CRLM-2), a typical heterodimeric cytokine receptor
consisting of a TSLP binding subunit (TSLPRα) and the α-subunit of the IL-7
receptor (IL-7Rα). TSLPR mRNA has been detected on many immune cell types,
including dendritic cells (DCs), T cells, B cells, mast cells, NKT cells and
monocytes as well as in tissues from heart, skeletal muscle, kidney and liver.
TSLPR has low affinity for TSLP, but in combination with IL-7Rα generates a
high affinity binding site for TSLP and triggers signaling. The TSLPR regulates
target gene expression via the JAK/STAT signalling pathway with participation
of signal transducers and activators of transcription STAT3, STAT5 and STAT1.
Genetic, experimental, and clinical evidence suggests that the TSLP-TSLPR
pathway is associated with the pathogenesis of allergic diseases such as atopic
dermatitis (AD) and asthma.
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