TNF-α Protein, Rabbit,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Rabbit
Synonyms	Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2 (TNF-a)
Accession	P04924
Amino Acid Sequence	Val78-Leu235
Expression System	E.coli
Molecular Weight	17.5kDa (Reducing)
Purity	＞95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4.
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.D Pennica, et al. (1984) Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin. Nature.312(5996):724-9. DOI: 10.1038/312724a0. 2. S A Nedospasov, et al. (1986) Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome. Cold Spring Harb Symp Quant Biol.51(1) 1:611-24. DOI: 10.1101/sqb.1986.051.01.073.

Background

Tumor Necrosis Factor alpha (TNF-α), is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. TNF-α exerts many of its effects by binding to either a 55 kDa cell membrane receptor termed. TNF-α activates signals through two receptors, TNF-R1, which is expressed on most cell types, and TNF-R2, which is expressed mainly on immune cells. TNF-α can have many functions including, to stimulate of phagocytosis in macrophages, to chemoattract neutrophils, to increase insulin resistance and to induce fever.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.