IL-2 Protein, Mouse,UA BIOSCIENCE_specification/price/image

Product Detail
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Product Specification

Species	Mouse
Synonyms	Interleukin-2蛋白；IL-2蛋白;aldesleukin; interleukin 2; interleukin-2; IL-2; IL2; T-cell growth facter; T cell growth factor; TCGF ; REF: C1025
Accession	P04351
Amino Acid Sequence	Ala21-Gln169
Expression System	E.coli
Molecular Weight	18 kDa (Reducing)
Purity	＞95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	20mM Sodium Citrate, pH3.0.
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1. Ma, A. et al. (2006) Annu. Rev. Immunol. 24:657. 2. Gaffen, S.L. and K.D. Liu (2004) Cytokine 28:109. 3. Kashima, N. et al. (1985) Nature 313:402. 4. Matesanz, F. et al. (1993) Immunogenetics 38:300. 5. Mosmann, T.R. et al. (1987) J. Immunol. 138:1813. 6. Liparoto, S.F. et al. (2002) Biochemistry 41:2543. 7. Wang, X. et al. (2005) Science 310:1159. 8. Bodnar, A. et al. (2008) Immunol. Lett. 116:117. 9. Jaleco, S. et al. (2003) J. Immunol. 171:61. 10. Malek, T.R. (2003) J. Leukoc. Biol. 74:961. 11. Laurence, A. et al. (2007) Immunity 26:371. 12. Kryczek, I. et al. (2007) J. Immunol. 178:6730. 13. Afzali, B. et al. (2007) Clin. Exp. Immunol. 148:32. 14. Fehervari, Z. et al. (2006) Trends Immunol. 27:109.

Background

Interleukin 2 (IL 2), also termed T-cell growth factor, is a member of the cytokine family which includes IL-4, IL-7, IL-9, IL-15 and IL-21. Each member of this family has a four alpha helix bundle. IL-2 signals through the IL-2 receptor, a complex consisting of tree subunits, termed alpha, beta and gamma. The IL-2 R gamma is shared by cytokine receptors of all members of cytokine family. Mature mouse IL2 shares 56% and 73% aa sequence identity with human and rat IL2, respectively. IL-2 is produced by CD4+ T cell, CD8+ T cells, gamma δ T cells, B cells, dendritic cells and eosinophils, and plays a vital role in key function of the immune system, tolerance and immunity, primarily via its potent stimulatory activity for T cells.Thus, IL2 may be a key cytokine in the natural suppression of autoimmunity.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.