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TMEM149/IGFLR1 Fc Chimera Protein, Human
TMEM149/IGFLR1 Fc Chimera Protein, Human
Place of Origin:
Singapore
Brand:
UA BIOSCIENCE
Model:
UA010713-100μg
Price:
604
Hits:
Updated:
8/27/2025
  • Product Detail
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    Product Specification


    SpeciesHuman
    SynonymsU2AF1L4
    AccessionQ9H665
    Amino Acid SequenceSer23-Pro163, with C-hIgG1 Fc
    Expression SystemHEK293
    Molecular Weight43-55kDa (Reducing)
    Purity>95% by SDS-PAGE
    Endotoxin<0.1EU/μg
    ConjugationUnconjugated
    Physical AppearanceLyophilized Powder
    Storage BufferPBS, pH7.4.
    ReconstitutionReconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
    Stability & Storage· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.
    Reference

    Wenjing Song, Xin He, Pengju Gong, Yan Yang, Sirui Huang, Yifan Zeng, Jingwei Zhang. IGFLR1 as a Novel Prognostic Biomarker in Clear Cell Renal Cell Cancer Correlating With Immune Infiltrates. Front Mol Biosci. 2020 Nov 26;7:565173.eCollection 2020.

    Background

    Insulin Growth Factor-Like receptor 1 (IGFLR1), also known as transmembrane protein 149 (TMEM149), is a protein encoding gene located on chromosome 19 and is widely expressed in lymph nodes, spleen and kidney. Although studies have shown that high expression level of IGFLR1 could predict poor survival among patients with ccRCC (Clear cell renal cell carcinoma), the mechanism of the cancer-promoting effect of IGFLR1 has been still unclear and previous studies were limited to carbohydrate metabolism. Adrian et al. found that IGFLR1 was similar in structure to the tumor necrosis factor receptor family (TNFRs) and considered to be a novel receptor in the TNFRs. IGFLR1 may be a tumor immune-related molecule. However, the potential function and prognostic value of IGFLR1 in tumor progression and tumor immunology remained unclear.

    bio-equip.cn
    AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
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