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IL13RA2/IL13R Fc Chimera Protein, Human
IL13RA2/IL13R Fc Chimera Protein, Human
Place of Origin:
Singapore
Brand:
UA BIOSCIENCE
Model:
UA010794-100μg
Price:
560
Hits:
Updated:
8/27/2025
  • Product Detail
  • Company Profile

    Product Specification


    SpeciesHuman
    SynonymsIL-13 receptor subunit alpha-2, IL-13R subunit alpha-2, IL-13R-alpha-2, IL-13RA2, nterleukin-13-binding protein, Interleukin-13 receptor subunit alpha-2, IL13RA2
    AccessionQ14627
    Amino Acid SequenceAsp27-Arg343, with C-terminal hIgG1 Fc
    Expression SystemHEK293
    Molecular Weight

    73-89kDa (Reducing)

    Purity>95% by SDS-PAGE
    Endotoxin<0.1EU/μg
    ConjugationUnconjugated
    TagHuman Fc Tag
    Physical AppearanceLyophilized Powder
    Storage BufferPBS, pH7.4.
    Reconstitution

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

    Stability & Storage

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

    Reference

    Kawakami K, Kawakami M, Puri R. Specifically targeted killing of interleukin-13 (IL-13) receptor-expressing breast cancer by IL-13 fusion cytotoxin in animal model of human disease. Mol Cancer Ther. 2004; 3:137–147. Valverde A, Povedano E, Montiel V, Yanez-Sedeno P, Garranzo-Asensio M, Barderas R, Campuzano S, Pingarron J. Electrochemical immunosensor for IL-13 Receptor alpha2 determination and discrimination of metastatic colon cancer cells. Biosens Bioelectron. 2018; 117:766–772. Okamoto H, Yoshimatsu Y, Tomizawa T, Kunita A, Takayama R, Morikawa T, Komura D, Takahashi K, Oshima T, Sato M, Komai M, Podyma-Inoue K, Uchida H, Hamada H, Fujiu K, Ishikawa S, Fukayama M, Fukuhara T, Watabe T. Interleukin-13 receptor alpha2 is a novel marker and potential therapeutic target for human melanoma. Sci Rep. 2019; 9:1281. Husain S, Puri R. Interleukin-13 receptor-directed cytotoxin for malignant glioma therapy: from bench to bedside. J Neurooncol. 2003; 65:37–48. Tu M, Wange W, Cai L, Zhu P, Gao Z, Zheng W. IL-13 receptor alpha2 stimulates human glioma cell growth and metastasis through the Src/PI3K/Akt/mTOR signaling pathway. Tumour Biol. 2016; 37:14701–14709. D.D. Donaldson, M.J. The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1. J. Immunol., 161 (1998), pp. 2317-2324

    Background

    Interleukin-13 receptor subunit alpha-2 (IL13RA2) is a high-affinity membrane receptor of IL-13 and is abundantly expressed in a variety of tumors, such as pancreatic cancer, ovarian cancer, breast cancer, colon cancer and melanoma. IL13RA2 is a glycosylated protein containing four potential glycosylation sites. IL13RA2 was initially considered a second, decoy receptor for interleukin 13 (IL-13). IL13RA2 is upregulated during helminthic and parasitic infections (i.e. schistosomiasis) as IgE is a key molecule in the fight against parasites and IL-13 is required for the IgE switching. A IL13RA2, an immunotherapeutic target, is considered a promising direction for the treatment of glioma.

    bio-equip.cn
    AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
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