Biotinylated Fc γ RI/CD64 His&Avi Tag Protein, Mouse,UA BIOSCIENCE_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Mouse
Synonyms	FCGR1A,FCG1,FCGR1,IGFR1,CD64,CD64A,FCRI
Accession	P26151
Amino Acid Sequence	Glu25-Pro297, with C-terminal His+Avi tag
Expression System	HEK293
Molecular Weight	43-53kDa (Reducing)
Purity	＞95% by SDS-PAGE
Endotoxin	<1EU/μg
Conjugation	Unconjugated
Tag	Avi Tag, His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4.
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1. Joan Cid, Reyes Aguinaco, Rafael Sánchez, Graciano García-Pardo, Andreu Llorente: Neutrophil CD64 expression as marker of bacterial infection: A systematic review and meta-analysis. Journal of Infection, Volume 60, Issue 5, May 2010, Pages 313-319.

Background

Fc γ RI, also known as CD64, is an integral cell membrane glycoprotein that transmits activation signals through the associated Fc R γ chain, commonly referred to as Fc-γ receptor 1 (Fc γ RI), and the high affinity recognition of IgG by Fc γ RI allows it to trigger effector responses at lower low IgG concentrations in early immune responses. After binding to IgG, CD64 interacts with an accessory chain called the common gamma chain, which has an ITAM motif necessary for triggering the cell and for activation. It is usually constitutively expressed on monocytes and macrophages, and can be induced by neutrophils and eosinophils, where its expression is upregulated in bacterial infections and sepsis.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.