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Human S100A4 Protein, His tag
Human S100A4 Protein, His tag
Place of Origin:
Singapore
Brand:
Starter
Model:
S0A0124-25μg
Price:
185
Hits:
Updated:
8/27/2025
  • Product Detail
  • Company Profile

    Product Specification


    SpeciesHuman
    SynonymsProtein S100-A4, Calvasculin, Metastasin, Placental calcium-binding protein, Protein Mts1, S100 calcium-binding protein A4, CAPL, MTS1
    AccessionP26447
    Amino Acid Sequence

    Protein sequence (P26447, Met1-Lys101, with C-His tag) MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMSNLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK

    Expression SystemHEK293
    Molecular WeightPredicted MW: 13.4 kDa Observed MW: 13.4 kDa
    Purity>95% by SDS-PAGE
    Endotoxin<0.1EU/μg
    ConjugationUnconjugated
    Tagwith C-His tag
    Physical AppearanceLyophilized Powder
    Storage BufferLyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.
    ReconstitutionReconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
    Stability & Storage

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

    Background

    Protein S100-A4 (S100A4) is a protein that in humans is encoded by the S100A4 gene. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A4, a member of the S100 calcium-binding protein family secreted by tumor and stromal cells, supports tumorigenesis by stimulating angiogenesis. Research demonstrated that S100A4 synergizes with vascular endothelial growth factor (VEGF), via the RAGE receptor, in promoting endothelial cell migration by increasing KDR expression and MMP-9 activity. S100A4 is highly associated with components of the cytoskeleton and when this gene is upregulated, it changes the cell’s morphology, making it more susceptible to invasion from proteins, such as cathepsin B and cyclin B1, that contribute to metastasis.

    bio-equip.cn
    AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
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