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Human ApoE3 Protein, His tag
Human ApoE3 Protein, His tag
Place of Origin:
Singapore
Brand:
Starter
Model:
S0A9058-25μg
Price:
170
Hits:
Updated:
8/27/2025
  • Product Detail
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    Product Specification


    SpeciesHuman
    SynonymsApolipoprotein E, Apo-E, APOE
    AccessionP02649
    Amino Acid Sequence

    Protein sequence (P02649, Lys19-His317, with C-His tag) KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH

    Expression SystemHEK293
    Molecular Weight

    Predicted MW: 35.9 kDa Observed MW: 35-40 kDa


    Purity>90% by SDS-PAGE
    Endotoxin<0.1EU/μg
    ConjugationUnconjugated
    Tagwith C-His tag
    Physical AppearanceLyophilized Powder
    Storage BufferLyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.
    ReconstitutionReconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
    Stability & Storage

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

    Background

    Apolipoprotein E (Apo-E) is a protein involved in the metabolism of fats in the body of mammals. A subtype is implicated in Alzheimer's disease and cardiovascular diseases. Apo-E belongs to a family of fat-binding proteins called apolipoproteins. In the circulation, it is present as part of several classes of lipoprotein particles, including chylomicron remnants, VLDL, IDL, and some HDL. Apo-E interacts significantly with the low-density lipoprotein receptor (LDLR), which is essential for the normal processing (catabolism) of triglyceride-rich lipoproteins. In peripheral tissues, Apo-E is primarily produced by the liver and macrophages, and mediates cholesterol metabolism. In the central nervous system, Apo-E is mainly produced by astrocytes and transports cholesterol to neurons via Apo-E receptors, which are members of the low density lipoprotein receptor gene family. Apo-E is the principal cholesterol carrier in the brain. APOE qualifies as a checkpoint inhibitor of the classical complement pathway by complex formation with activated C1q.

    bio-equip.cn
    AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
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