Human INSM1, His tag,Starter_specification/price/image

Product Detail
Company Profile

Product Specification

Species	Human
Synonyms	Zinc finger protein IA-1, IA1
Accession	Q01101
Expression System	HEK293
Molecular Weight	Theoretical:12.1kDa Actual:16kDa
Purity	＞95% by SDS-PAGE
Endotoxin	<1EU/mg
Tag	with C-10*His
Physical Appearance	Lyophilized Powder
Storage Buffer	Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, 1mM EDTA, pH7.4.
Stability & Storage	12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.

Background

INSM1 is a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. INSM1 was originally isolated from an insulinoma subtraction library (1). Subsequent studies revealed that INSM1 expression is quite specific for neuroendocrine tumors and is absent from other non-neuroendocrine tumors. An extensive neuroendocrine tumor marker analysis in lung cancer demonstrated that 97% (30/31) of small cell lung carcinoma cell lines are positive for INSM1 expression. INSM1 expression also appears in nonsmall cell lung carcinoma with a neuroendocrine phenotype. INSM1 showed a high concordance with the other neuroendocrine markers l-dopa decarboxylase and chromogranin A. In addition, several microarray gene expression profiling experiments of small cell lung cancer cells identified INSM1 as a highly specific marker that is abundantly expressed in neuroendocrine lung tumors. INSM1 was identified as a prominent differential marker for SCLC along with Hash1 and gastrin-releasing peptide.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.