IGFBP-4 (insulin-like growth factor binding protein 4) binds to insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF effects in vitro. All members of the IGFBP family bind to IGF-I and IGF-II with approximately equal affinity, but IGFBP-4 binds to IGF2 better than IGF1. It contains a N-terminal domain of IGFBP and a thyroglobulin 1 type domain. IGFBP prolongs the half-life of insulin-like growth factor and has been shown to inhibit or stimulate the stimulative effects of insulin-like growth factor on cell culture. They alter the interaction of IGF with its cell surface receptors. IGFBP-4 is a unique protein that consistently inhibits multiple cancer cells in vivo and in vitro.This product is the recombinant human IGFBP-4 protein expressed from human 293 cells (HEK293).
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