Rabbit Anti-FMC63 Antibody (S-2163-77),Starter_specification/price/image

Product Detail
Company Profile

Product Specification

Host	Rabbit
Antigen	FMC63 scFv
Immunogen	Recombinant Protein
Clone Number	S-2163-77
Antibody Type	Recombinant mAb
Isotype	IgG
Application	FCM
Purification	Protein A
Concentration	2 mg/ml
Conjugation	Unconjugated
Physical Appearance	Liquid
Storage Buffer	PBS pH7.4
Stability & Storage	12 months from date of receipt / reconstitution, 2 to 8 掳C as supplied.

Dilution

application	dilution	species
FCM	1:2000	Species independent

Background

FMC63 scFv (single-chain variable fragment) is a recombinant protein derived from the variable regions (VH and VL) of the anti-CD19 monoclonal antibody FMC63, linked by a flexible peptide spacer (e.g., (Gly鈧凷er)鈧?. It specifically binds to the B-cell surface antigen CD19 with high affinity (KD ~1-10 nM) and is a key targeting component in FDA-approved CAR-T therapies, such as Kymriah庐. The humanized FMC63 scFv retains potent antigen recognition while minimizing immunogenicity, making it highly effective in treating B-cell malignancies, including acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL). Ongoing research focuses on optimizing its affinity, stability, and functionality to enhance the safety and efficacy of CAR-T cell therapies.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.