MACIR (macrophage immunometabolism regulator), previously known as C5orf30, is a protein that plays a crucial role in regulating macrophage function and has potential applications in treating chronic inflammation. It is a 206 amino acid protein with no significant similarity to any other human protein. MACIR is highly conserved in vertebrate genomes and is expressed in various tissues, including the colon and brain. It functions as a negative regulator of tissue damage and modulates the activity of synovial fibroblasts and macrophages, which are associated with rheumatoid arthritis. MACIR enhances the resolution of inflammation and wound repair functions mediated by M2 macrophages by inhibiting glycolysis. Additionally, it may play a role in protein trafficking through its interaction with UNC119 and UNC119B cargo adapters and in ciliary membrane localization via its interaction with UNC119B.
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