CD192, also known as CCR2, is a seven-transmembrane, G-protein-coupled receptor that belongs to the beta chemokine receptor family. It is primarily expressed on monocytes, macrophages, basophils, dendritic cells, and some T cells. CD192 acts as a receptor for several chemokines, including monocyte chemoattractant protein-1 (MCP-1/CCL2), MCP-2/CCL8, MCP-3/CCL7, and MCP-4/CCL13. This receptor plays a crucial role in mediating monocyte chemotaxis and is involved in various inflammatory responses, such as the recruitment of monocytes into tissues during atherosclerosis, rheumatoid arthritis, and tumor formation. Additionally, CD192 has been implicated in the pathogenesis of certain cancers, where it controls the recruitment of activated macrophages that can either promote tumor cytotoxicity or inhibit tumor growth.
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