CD36 is a multifunctional transmembrane glycoprotein belonging to the class B scavenger receptor family, widely expressed in various cell types including macrophages, endothelial cells, adipocytes, and muscle cells. It plays a crucial role in fatty acid uptake and transport, acting as a receptor for a diverse range of ligands such as oxidized low-density lipoprotein (oxLDL), apoptotic cells, thrombospondin, and pathogens like malaria-infected erythrocytes. Structurally, CD36 is a heavily glycosylated protein with two transmembrane domains, a large extracellular loop, and short intracellular tails. Its functions span from facilitating lipid metabolism and mediating immune responses to contributing to pathological conditions like atherosclerosis and diabetes. Additionally, CD36 is involved in cellular signaling pathways related to inflammation and angiogenesis.
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