FTH1, also known as Ferritin Heavy Chain 1, is a protein-coding gene that plays a crucial role in iron metabolism. It encodes a subunit of ferritin, the major intracellular iron storage protein in both prokaryotic and eukaryotic organisms. The ferritin protein is composed of 24 subunits of heavy and light chains, with FTH1 being the heavy chain component. This protein helps catalyze the oxidation of Fe虏鈦?to Fe鲁鈦? facilitating iron storage in a soluble and non-toxic form. Additionally, FTH1 possesses ferrous iron binding activity and is involved in various biological processes, including immune response, cell proliferation, and protection against oxidative stress. Defects in the FTH1 gene are associated with several diseases, such as neurodegenerative disorders and iron overload conditions like Hemochromatosis Type 5.
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