Rab32 is a small GTPase protein belonging to the RAS oncogene family, involved in various cellular processes including mitochondrial dynamics, autophagy, and vesicle trafficking. It anchors the type II regulatory subunit of protein kinase A to the mitochondrial outer membrane, facilitating mitochondrial fission. Rab32 also interacts with LRRK2, a protein implicated in Parkinson's disease, and its variants have been identified as a susceptibility factor for familial Parkinson's disease. In cancer biology, Rab32 promotes glioblastoma migration and invasion by regulating ERK/Drp1-mediated mitochondrial fission. Additionally, it plays a role in the degradation of mitochondrial-proximal ER membranes through autophagy, mediated by its effector reticulon 3L.
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