SLAMF8, also known as B-lymphocyte activator macrophage expressed (BLAME) or CD353, is a single-pass type I membrane protein belonging to the SLAM (Signaling Lymphocyte Activation Molecule) family. It is characterized by the presence of Ig-like domains and is primarily expressed in immune-related tissues such as the lymph node, spleen, and thymus. SLAMF8 has been identified as a potential new immune checkpoint molecule, with its high expression associated with poor prognosis in colorectal cancer. This protein is involved in immune regulation and may play a role in various immune responses, including those related to inflammation and autoimmune diseases.