Alexa Fluor® 647 Rat Anti-Mouse CD184 Antibody (S-R670),Starter_specification/price/image

Product Detail
Company Profile

Product Specification

Host	Rat
Antigen	Mouse CD184
Synonyms	C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; Fusin; Leukocyte-derived seven transmembrane domain receptor (LESTR); Pre-B-cell-derived chemokine receptor (PB-CKR); Stromal cell-derived factor 1 receptor (SDF-1 receptor); Cxcr4; Cmkar4; Lestr; Sdf1r
Location	Lysosome, Endosome, Cell membrane, Cell junction
Accession	P70658
Clone Number	S-R670
Antibody Type	Rat mAb
Isotype	IgG2b,k
Application	FCM
Reactivity	Ms
Positive Sample	C57BL/6 mouse thymocytes
Purification	Protein G
Concentration	0.05mg/ml
Conjugation	Alexa Fluor® 647
Physical Appearance	Liquid
Storage Buffer	PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300
Stability & Storage	12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.

Dilution

application	dilution	species
FCM	5μl per million cells in 100μl volume	Ms

Background

CD184, also known as CXCR4, is a CXC chemokine receptor encoded by the CXCR4 gene. It is a G protein-coupled receptor that specifically binds to stromal-derived factor-1 (SDF-1, also known as CXCL12), which is important for lymphocyte chemotaxis, hematopoietic stem cell homing, and quiescence. CXCR4 is also a co-receptor for HIV infection in CD4+ T cells, particularly for T-cell tropic HIV strains. Additionally, CXCR4 is involved in neuronal guidance during embryogenesis and adult life, and its dysregulation has been implicated in various diseases, including cancer and epilepsy.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.