The ASGR1 protein, also known as the asialoglycoprotein receptor 1, is a key component of the asialoglycoprotein receptor complex, which is involved in the recognition and uptake of glycoproteins with terminal galactose or N-acetylgalactosamine residues. This receptor is primarily expressed in hepatocytes and plays a crucial role in the clearance of circulating glycoproteins, contributing to the maintenance of homeostasis. The ASGR1 gene is located on chromosome 17 and encodes a 46 kDa glycoprotein that forms a complex with the ASGR2 subunit. Recent studies have also highlighted the potential role of ASGR1 in various metabolic processes and its implications in diseases such as atherosclerosis.
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