Ferritin Light Chain (FTL) is a critical component of the ferritin complex, which is essential for iron homeostasis. It stores iron in a soluble, non-toxic form and facilitates its delivery to cells. Structurally, FTL, along with heavy subunits, forms a spherical shell that allows iron entry through pores. Mutations in the C-terminus can disrupt pore formation, impacting iron accumulation. FTL plays a significant role in kidney development by mediating iron uptake in capsule cells, which is crucial for organogenesis.
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