EHD2, a member of the EH domain-containing protein family, is primarily located in the plasma membrane but can also be found in the cytoplasm and endosomes. It functions as a nuclear-cytoplasmic shuttle protein and acts as a corepressor of transcription within the nucleus to inhibit gene transcription. EHD2 plays a key role in endocytic transport, being involved in the formation and maintenance of endosomal tubules and vesicles, which are essential for intracellular transport of proteins and other substances. The N-terminus of EHD2 is attached to the cell membrane, while its C-terminus binds to actin-binding proteins, linking the actin cytoskeleton to membrane curvature and promoting cell endocytosis. Additionally, EHD2 is associated with membrane protein trafficking, receptor signaling, glucose metabolism, and lipid metabolism, highlighting its multifaceted role in cellular processes and its potential implications in diseases such as cancer and metabolic disorders.
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