ENT2, or Equilibrative Nucleoside Transporter 2, is a bidirectional transporter embedded in the biological membrane and is found in most tissue and cell types. It plays a crucial role in mediating the uptake of purine and pyrimidine nucleosides and nucleobases, as well as transporting a variety of nucleoside-derived drugs, which are predominantly used in anticancer therapy. The high expression of ENT2 has been correlated with advanced stages of different types of cancers, making it a significant interest as a potential therapeutic target. Furthermore, ENT2 is known to play critical roles in signaling pathways and cell cycle progression.
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