DCAMKL1, or doublecortin and CaM kinase-like 1, is a protein that has homology to doublecortin (DCX) and is involved in regulating microtubule polymerization. It consists of an N-terminal region that is similar to DCX and a C-terminal domain that encodes a putative Ca2+/calmodulin-dependent protein kinase. It is expressed in the central and peripheral nervous systems, particularly in migrating neuronal populations, and is associated with microtubules. DCAMKL1 has been shown to associate with microtubules, stimulate the polymerization of purified tubulin, and form aster-like microtubule structures. Overexpression of DCAMKL1 can lead to microtubule bundling in cell lines and cultured primary neural cells. DCAMKL1 has also been implicated in the regulation of osteoblast function. Studies have shown that knocking down DCAMKL1 in mesenchymal stem cells enhances their differentiation into osteoblasts, and DCAMKL1 gene knockout mice exhibit increased osteoblast function, bone formation rate, and bone density.
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