CD90.2 protein, also known as Thy-1.2, is a 25-37 kDa glycosylphosphatidylinositol (GPI)-anchored protein with a V-type immunoglobulin domain. It is one of the two murine isoforms of the Thy-1 protein, distinguished mainly by the 89th amino acid, where Thy-1.1 carries an arginine and Thy-1.2 carries a glutamine. CD90.2 is expressed in various cell types, including T cells and fibroblasts of certain mouse strains, and plays a role in cell-to-cell and cell-matrix interactions. It is involved in axonal growth and neuronal regeneration, T cell activation and apoptosis, adhesion and migration of leukocytes and melanoma cells, as well as proliferation and migration of fibroblasts in wound healing, inflammation, and fibrosis.
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