MEK1/2 (Mitogen-Activated Protein Kinase Kinase 1 and 2) are crucial components within the MAPK (Mitogen-Activated Protein Kinase) signaling pathway, belonging to the protein kinase family. They are activated by upstream kinases such as RAF, which then phosphorylate and activate downstream ERK (Extracellular Signal-Regulated Kinase) protein kinases, thereby promoting cellular processes like growth, differentiation, and proliferation. In many cancers, MEK1/2 activity is significantly elevated, enabling tumor cells to proliferate and grow unchecked. Therefore, inhibiting the MEK1/2 signaling pathway is considered a vital anticancer strategy.
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