Stat5, which stands for Signal Transducer and Activator of Transcription 5, is a transcription factor that plays a pivotal role in cellular signaling pathways. It is a key player in cellular signaling, particularly in response to cytokine receptors such as IL-2, IL-3, IL-5, and GM-CSF. Upon binding of these cytokines to their respective receptors, a cascade of signaling events is triggered, ultimately leading to the phosphorylation of Stat5 (e.g., at Tyr694). The phosphorylated Stat5 forms dimers and translocates to the nucleus, where it acts as a transcription factor to regulate the expression of target genes.
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