Stat3 is a transcription factor that plays a fundamental role in mediating cellular responses to a wide range of cytokines, growth factors, and oncogenic signals. Stat3 is activated by the phosphorylation of specific tyrosine residues, typically Tyr705, upon stimulation by cytokines such as IL-6, IL-10, and EGF, among others. Once phosphorylated, Stat3 forms homodimers or heterodimers with other Stat proteins and translocates to the nucleus, where it binds to specific DNA sequences called Stat-responsive elements (SREs) in the promoter regions of target genes. This binding initiates transcription of genes involved in cell proliferation, survival, differentiation, migration, angiogenesis, and immune function.
中文
