AKT protein, also known as protein kinase B (PKB) or RAC-PK, is a key molecule in cellular signaling pathways that belongs to the serine/threonine protein kinase family. AKT protein exerts extensive biological effects by phosphorylating downstream target proteins, including mTOR, GSK3β, FoxO, and others. These targets are involved in various biological processes, such as cell growth, proliferation, differentiation, and apoptosis. However, abnormal activation of AKT protein is closely related to the development of multiple diseases, including cancer, diabetes, and neurodegenerative diseases.