CCR7 protein, also known as CC-chemokine receptor 7, is a G protein-coupled receptor encoded by the CCR7 gene. CCR7 is mainly distributed on the surfaces of lymphocytes, dendritic cells, monocytes, and certain epithelial cells, and its expression pattern in tissues is very strict and specific. CCR7 plays an important role in regulating the migration and localization of lymphocytes and dendritic cells in the body, promoting the activation and proliferation of lymphocytes, and regulating the differentiation and function of immune cells. CCR7 signaling pathways can regulate inflammatory responses and immune responses by activating various signaling molecules such as PI3K, MAPK, and NF-κB. Furthermore, CCR7 is closely related to autoimmune diseases such as multiple sclerosis (MS), rheumatoid arthritis (RA), and psoriasis. For example, in MS, increased levels of CCL19 in the cerebrospinal fluid are associated with increased T cell infiltration and increased proinflammatory CCR7-positive dendritic cells in the cerebrospinal fluid of MS patients. Blocking CCR7 signaling seems to reduce the pathogenic processes mediated by cerebrospinal fluid and immune cells in MS. Similarly, CCR7 is also involved in the pathogenesis of RA and psoriasis.
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