Home >Products> Reagents >Antibody> S-RMab® Cyclin D1 Recombinant Rabbit mAb (SDT-R423)
Reagents:  Molecular Biology   Biochemistry   Cell Biology   ELISA / Diagnostic Kits   Antibody   Serum/Medium   Other Reagents  
S-RMab® Cyclin D1 Recombinant Rabbit mAb (SDT-R423)
S-RMab® Cyclin D1 Recombinant Rabbit mAb (SDT-R423)
Place of Origin:
Singapore
Brand:
Starter
Model:
S0B2322-25μl
Price:
100
Hits:
Updated:
8/27/2025
  • Product Detail
  • Company Profile

    Product Specification


    HostRabbit
    SynonymsG1/S-specific cyclin-D1; B-cell lymphoma 1 protein (BCL-1); BCL-1 oncogene; PRAD1 oncogene; CCND1; BCL1; PRAD1
    LocationNucleus, Cytoplasm
    AccessionP24385
    Clone NumberSDT-R423
    Antibody TypeRecombinant mAb
    IsotypeIgG
    ApplicationWB, IHC-P, ICC, IP
    ReactivityHu, Ms, Rt
    PurificationProtein A
    Concentration0.5 mg/ml
    ConjugationUnconjugated
    Physical AppearanceLiquid
    Storage Buffer

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

    Stability & Storage

    12 months from date of receipt / reconstitution, -20 °C as supplied

    Dilution


    applicationdilutionspecies
    WB1:1000
    IP1:50
    IHC-P1:500
    ICC1:500

    Background

    Cyclin D1 is a protein that in humans is encoded by the CCND1 gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDKs (cyclin-dependent kinase). Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Immunohistochemical staining of cyclin D1 antibodies is used to diagnose mantle cell lymphoma. Besides, cyclin D1 has been found to be overexpressed in breast carcinoma. Its potential use as a biomarker was suggested.

    bio-equip.cn
    AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
Request Information
Request Information: yes no
Request Quotation: yes no
refresh

I agree to share my inquiry with the other matching suppliers.

Request Information

* Name:
Job Title:
* Tel:
Fax:
* E-mail:
Postcode:
Institution/Company:
Address:
* Country:
Request Information:
yes no
Request Quotation:
yes no
* Message:
* Verification Code:
refresh
I agree to share my inquiry to the other matching suppliers.