KIM-1 Recombinant Rabbit mAb (SDT-932-14-2),Starter_specification/price/image

Product Detail
Company Profile

Product Specification

Host	Rabbit
Synonyms	Kidney injury molecule 1 (KIM-1), T-cell immunoglobulin and mucin domain-containing protein 1 (TIMD-1), T-cell immunoglobulin mucin receptor 1 (TIM; TIM-1), T-cell membrane protein 1
Immunogen	Recombinant Protein
Accession	Q96D42
Clone Number	SDT-932-14-2
Antibody Type	Recombinant mAb
Isotype	IgG
Application	Lateral Flow, Sandwich ELISA
Reactivity	Hu
Cross Reactivity	Does not recognize TIM-3, TIM-4
Purification	Protein A
Concentration	2 mg/ml
Purity	>95% by HPLC
Conjugation	Unconjugated
Physical Appearance	Liquid
Storage Buffer	PBS pH7.4, 0.03% Proclin 300
Stability & Storage	12 months from date of receipt, 2 to 8 °C as supplied

Background

Preclinical subtractive hybridization screens identified kidney injury molecule 1 (Kim-1) as a gene that is markedly up-regulated in ischemic rat kidneys. Downstream proteomic studies have also shown KIM-1 to be one of the most highly induced proteins in the kidney after AKI in animal models. KIM-1 is a transmembrane protein that is not expressed in normal kidney but is specifically upregulated in dedifferentiated proximal tubule cells after ischemic or nephrotoxic AKI. It has been identified as a phosphatidylserine receptor that transforms epithelial cells into phagocytes by recognizing cell surface-specific epitopes expressed by apoptotic tubular epithelia. A proteolytically processed extracellular domain of KIM-1 is detectable in the urine soon after AKI. KIM-1 represents a promising biomarker for the early diagnosis of AKI and its clinical outcomes. The recent availability of a rapid urine dipstick test for KIM-1 will facilitate its further evaluation in preclinical and clinical studies.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.