P27 is a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins. It binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. It is often referred to as a cell cycle inhibitor protein because its major function is to stop or slow down the cell division cycle. p27 is considered a tumor suppressor because of its function as a regulator of the cell cycle. In cancers it is often inactivated via impaired synthesis, accelerated degradation, or mislocalization. p27 can also be mislocalized to the cytoplasm in order to facilitate metastasis.
中文
