Transcription factor jun-B is a protein that in humans is encoded by the JUNB gene. Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'. In addition, JunB proteins are important regulators of cytokine expression and the immune response in skin. Skin specific JunB deficiency in mice has been associated with numerous skin pathologies including psoriasis-like disease, systemic lupus erythematosus, ulcerative skin lesions, prolonged inflammation with delayed tissue remodeling19 and myeloproliferative disease.
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