p14ARF Recombinant Rabbit mAb (S-R244),Starter_specification/price/image

Product Detail
Company Profile

Product Specification

Host	Rabbit
Antigen	p14ARF
Synonyms	Tumor suppressor ARF, Alternative reading frame (ARF), Cyclin-dependent kinase inhibitor 2A, CDKN2A, MLM
Location	Nucleus
Accession	Q8N726
Clone Number	S-R244
Antibody Type	Recombinant mAb
Application	WB, IHC-P, ICC, ICFCM, IP
Reactivity	Hu
Purification	Protein A
Concentration	0.5 mg/ml
Conjugation	Unconjugated
Physical Appearance	Liquid
Storage Buffer	PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300
Stability & Storage	12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution

application	dilution	species
WB	1:1000	null
IHC	1:100	null
ICFCM	1:500	null
ICC	1:500	null
IP	1:50	null

Background

p14ARF (also called ARF tumor suppressor, ARF, p14ARF) is an alternate reading frame protein product of the CDKN2A locus (i.e. INK4a/ARF locus). p14ARF is induced in response to elevated mitogenic stimulation, such as aberrant growth signaling from MYC and Ras (protein). It accumulates mainly in the nucleolus where it forms stable complexes with NPM or Mdm2. These interactions allow p14ARF to act as a tumor suppressor by inhibiting ribosome biogenesis or initiating p53-dependent cell cycle arrest and apoptosis, respectively.

AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.